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A SIMPLE PREPARATION OF N,N-DIMETHYL-N′-ALKYL (ARYL) SULFONYLFORMAMIDINES

✍ Scribed by Silva, A. L.; Covarrubias-Zúñiga, A.; Maldonado, L. A.


Book ID
121188753
Publisher
Taylor and Francis Group
Year
2002
Tongue
English
Weight
304 KB
Volume
34
Category
Article
ISSN
0030-4948

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Reactions of a-amino acids with ketones under hydrogenation conditions using 20% Pd(OH) 2 /C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50°C afforded N,N-di-alkylated amino acids i