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A simple method for preparation of N-mono- and N,N-di-alkylated α-amino acids

✍ Scribed by Yuntao Song; Anthony D. Sercel; Don R. Johnson; Norman L. Colbry; Kuai-Lin Sun; Bruce D. Roth

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 93 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01458-1

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✦ Synopsis

Reactions of a-amino acids with ketones under hydrogenation conditions using 20% Pd(OH) 2 /C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50°C afforded N,N-di-alkylated amino acids in excellent yields. This simple method has been used to synthesize N-mono-and N,N-di-alkylated amino acids on a scale of 200 g.

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