Reactions of a-amino acids with ketones under hydrogenation conditions using 20% Pd(OH) 2 /C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50ยฐC afforded N,N-di-alkylated amino acids i
A convenient method for the preparation of mono N-alkylated cyclams and cyclens in high yields
โ Scribed by Cong Li; Wing-Tak Wong
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 78 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Selective and high yield synthesis of mono N-substituted derivatives of cyclam and cyclen can be achieved by using a direct and general synthetic method with very mild reaction conditions.
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Monosaccharide 1,2-alkyl orthoesters are of considerable importance as precursors in the synthesis of glycosides and oligosaccharides1-4. For the preparation of orthoesters, Kochetkov and Bochkov2 have pointed out that acylglycosyl halides can be treated with an alcohol in the presence of silver oxi