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A simple preparation of bicuculline methiodide, a water-soluble GABA antagonist

✍ Scribed by S.F. Pong; L.T. Graham Jr.

Book ID
118861137
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
121 KB
Volume
58
Category
Article
ISSN
0006-8993

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Bicuculline methiodide (BMI), a y-aminobutyrate (GABA) antagonist, is a powerful convulsant agent when injected into the cerebral ventricles, amygdala, hippocampus, thalamus, neocortex, and deep prepiriform cortex in rats. In contrast, bilateral microinjection of BMI into the rat striatum confers pr