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Microinjections of the γ-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats

✍ Scribed by Esper A. Cavalheiro; Zuner A. Bortolotto; Lechoslaw Turski


Book ID
115797519
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
277 KB
Volume
411
Category
Article
ISSN
0006-8993

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✍ Lechoslaw Turski; Stefan Diedrichs; Thomas Klockgether; Michael Schwarz; Waldema 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 797 KB

Bicuculline methiodide (BMI), a y-aminobutyrate (GABA) antagonist, is a powerful convulsant agent when injected into the cerebral ventricles, amygdala, hippocampus, thalamus, neocortex, and deep prepiriform cortex in rats. In contrast, bilateral microinjection of BMI into the rat striatum confers pr