Synthesis of a water-soluble antagonist of aldosterone
β Scribed by N. I. Moleva; A. M. Veitsman; V. N. Petyunina
- Book ID
- 112408871
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 131 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0091-150X
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## Abstract magnified image A novel waterβsoluble __N__βmethylβDβaspartate (NMDA) receptor antagonist ATGDMAP **1** as synthesized and the effect of **1** on NMDA receptors was studied using voltageβclamp recordings of recombinant NMDA receptors expressed in __Xenopus__ oocytes. The compound **1**
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-lH-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a number of strategies were examined to achieve improve