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A simple, efficient synthesis of β-methylene phenylalanine. a new approach to the preparation of β,γ-unsaturated ←pha-amino acid enzyme substrate analogs

✍ Scribed by Ravi V.J. Chari; James Wemple

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
281 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

Several synthetic /J,f-unsaturated &amino acids have recently been developed as specific irreversible inhibitors of pyridoxal l,hosl,hate dependent enzymes. 1 A few naturally occurring P,d-unsaturated amino acids are known to function as specific enzyme inhibitors 2. including rhizobitoxine inhibition of p-cystathionase 3 and 2-aminolc-nethow trans-3-butenoic acid inhibition of aspartate aminotransferase.

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