A simple direct procedure for the regiospecific preparation of chloro aromatic compounds
β Scribed by Bay, Elliott; Timony, Peter E.; Leone-Bay, Andrea
- Book ID
- 120224723
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 275 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Reaction of a range of aromatic compounds with methoxyacetyl chloride and aluminium chloride in either nitromethane or carbon disulphide results in chloromethylation in good to excellent yield. ## Chloromethylation of aromatic compounds was a very widely used reaction for well over half a century
A brief route for preparation of the L-hexenulose 4 from D-glucal 1 via furan intermediates 2 and 3 is described. We have developed a simple and conceptually novel route to C-hexoses. The procedure is notably brief and overcomes many of the limitations of other methods. Until recently, synthetic i