✍ Scribed by Dennis W. Wong
No coin nor oath required. For personal study only.
a l i f o r n i a at Los Angeles, 12021 S. Willnington Avenue, h s Angeles, C a l i f . 90059 SUMMARY Hematoporphyrin derivative(HPD) , a f l u o r e s c e n t compound known t o be s e l e c t i v e l y accumulated i n neoplasms, is l a b e l e d with *Tc by a chemical method. Radiochemical analyses i n d i c a t e d that t h e l a b e l e d product c o n t a i n s an average of 91% 99mTc-HPD, 6% unbound 99mTc-(Sn)complex s p e c i e s and l e s s than 3% f r e e 99mTc. Data from a c i d p r e c i p i t a t i o n a n a l y s i s demonstrate t h e presence of two radiolabeled €IFTI f r a c t i o n s ; an i n s o l u b l e black p r e c i p i t a t e and a n a c i d s o l u b l e f r a c t i o n with a n average of 66% and 29% respectively.
The l a b e l i n g mechanism i s not known. Presumably, l a b e l i n g of HPD involves t h e formation of a coordinated complex v i t h reduced 99mTc forming a r a d i o a c t i v e metalloporphyrin compound.
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