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A simple and efficient method of preparing α-bromo carboxylic acids

✍ Scribed by Lian Hao Zhang; Jianxin Duan; Yuelian Xu; William R. Dolbier Jr.

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
117 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new and convenient method for ¢~-bromination of aliphatic carboxylic acids is reported. Heating carboxylic acids for 16 hours at 85 °C in trifluoroacetic acid with 1.5 equivalents of N-bromosuccinimide and a catalytic amount of concentrated H2SO4 leads to good yields of the respective cx-bromocarboxylic acids.

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