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A short synthesis of α-herbertenol featuring the use of a dihydropyranone as a 1,5-diketone synthon

✍ Scribed by David C. Harrowven; Joanne C. Hannam

Book ID
104260278
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
106 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The paper describes a short synthesis of oc-herbertenol. Key features are the addition of dihyropyranone 5 to an aryllithium to give 1,5-diketone 7; a titanium(0) mediated cyclisation of 7 to diol8and asequentialmethylation of 8 toherbertenol methyl ether 9.

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