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1,5-Diketones from 3,4-dihydropyranones: An application in the synthesis of (±)-α-herbertenol

✍ Scribed by David C. Harrowven; Joanne C. Hannam

Book ID
108379394
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
750 KB
Volume
55
Category
Article
ISSN
0040-4020

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Featuring the Use of a Dihydropyranone as a 1,5-Diketone Synthon. -A short synthesis of the antifungally active sesquiterpene α-herbertenol (VII) is described. Key steps are the addition of an aryllithium reagent to dihydropyranone (II), which is used as 1,5-diketone synthon, and a titanium promote