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Synthesis of hydrogenated heterocyclic compounds fromα-methylidene-1, 5-diketones. 4. Hydropyridines based on the reaction of 1,3,5-triphenyl-2-aminomethyl-4-methylidene-1,5-pentadione with primary amines

✍ Scribed by G. V. Pavel'; N. P. Bagrina; M. N. Tilichenko


Book ID
112326646
Publisher
Springer US
Year
1979
Tongue
English
Weight
223 KB
Volume
15
Category
Article
ISSN
0009-3122

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N-t-Butylacetamidines 1 on heating with methyl acrylate (2) at 200˚ gave the 4,5-dihydro-3H-pyridin-2one derivatives 5. Michael addition of the acetamidines 1 as their ene-1,1-diamine tautomers 1' to 2 and the subsequent cyclization of the adducts gave derivatives 5. Amidines 1 on reaction with trim