A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved Claisen orthoester rearrangement, Sharpless asymmetric dihydroxylation and intramolecular lactamisation of azido lactone as the key steps.
β¦ LIBER β¦
A short synthesis of (2S,3S)-3-hydroxypipecolic acid
β Scribed by Chavan, Subhash P.; Harale, Kishor R.; Pawar, Kailash P.
- Book ID
- 120545571
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 478 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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