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A short synthesis of (2S,3S)-3-hydroxypipecolic acid

✍ Scribed by Chavan, Subhash P.; Harale, Kishor R.; Pawar, Kailash P.


Book ID
120545571
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
478 KB
Volume
54
Category
Article
ISSN
0040-4039

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Asymmetric total synthesis of (2S,3S)-3-
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A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved Claisen orthoester rearrangement, Sharpless asymmetric dihydroxylation and intramolecular lactamisation of azido lactone as the key steps.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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