A Short Stereoselective Synthesis of a Cyclopropyl Analog of γ-Aminobutyric acid (GABA)
✍ Scribed by Mohapatra, Debendra K.
- Book ID
- 127364067
- Publisher
- Taylor and Francis Group
- Year
- 1999
- Tongue
- English
- Weight
- 302 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0039-7911
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## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.
A Simple and Efficient Synthesis of γ-Aminobutyric Acid (GABA) Derivatives. -The phase-transfer catalyzed reaction of N-(benzylidene)benzylamine (I) with some esters of cinnamic acid (II) offers a convenient and efficient route for the preparation of GABA derivatives (IV) (6 examples). -(DRYANSKA,