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A short asymmetric synthesis of 2,5-disubstituted pyrrolidines

✍ Scribed by Alan R. Katritzky; Xi-Lin Cui; Baozhen Yang; Peter J. Steel

Book ID
104258914
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
212 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel approach to chiral 2,5-disubsfituted pyrrolidines, starting from chiral 2-phenylglycinol, 1,5-dimethoxytetrahydrofiuan, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield.

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ChemInform Abstract: Asymmetric Synthesi
ChemInform Abstract: Asymmetric Synthesis of 2,4-Disubstituted Pyrrolidines.
✍ Q. WANG; N. A. SASAKI; P. POTIER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

Asymmetric Synthesis of 2,4-Disubstituted Pyrrolidines. -Starting with the chiral synthon (I), the 2,4-disubstituted pyrrolidines (VI) and (VIII) are synthesized enantiospecifically via the common intermediate (III). -(WANG, Q.;