Asymmetric Synthesis of 2,4-Disubstituted Pyrrolidines. -Starting with the chiral synthon (I), the 2,4-disubstituted pyrrolidines (VI) and (VIII) are synthesized enantiospecifically via the common intermediate (III). -(WANG, Q.;
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ChemInform Abstract: A Short Asymmetric Synthesis of 2,5-Disubstituted Pyrrolidines.
โ Scribed by A. R. KATRITZKY; X.-L. CUI; B. YANG; P. J. STEEL
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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Starting from the (R)-(-)-phenylglycinol derivative (I), the stereoselective synthesis of polyhydroxylated pyrrolidines [cf. (VIII)] and the indolizidine (XII) is based on the diastereoselective condensation of the chiral silyloxypyrrole (III) with aldehydes (IV). The preparation of the indolizidine