A new method converting thioamides to ketene S,S-acetals, which exhibits wide compatibility with olefin, ketone, ester and amide groups, has been described. Thioamides have proved to be synthetically very potential by the total synthesis of Vitamin Bl2 (construction of corrin molecule) by Woodward a
A Short and Simple Synthesis of Ketene Acetals
โ Scribed by Argade, A. B.; Joglekar, B. R.
- Book ID
- 117992920
- Publisher
- Taylor and Francis Group
- Year
- 1993
- Tongue
- English
- Weight
- 226 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0039-7911
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## SYNOPSIS A new, facile, and high-yield synthesis of ketene acetals derived from readily available and inexpensive starting materials has been developed. For example, an a,@-unsaturated aldehyde can be condensed with an alkane diol to afford a 2-vinyl substituted cyclic acetal. This latter compo
a-Aroyl substituted bis-ketene N,S-acetals 3-6 with a polyrnethylene linkage, N,N'-bis(l-methylthio-2-aroy1)vinyl polymethylene diamines, were synthesized by reactions between a-aroyl ketene dithioacetals 1 and polymethylene diamines 2 in moderate yields.