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A second RING to destroy p27Kip1

✍ Scribed by Hengst, Ludger

Book ID
109912340
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
158 KB
Volume
6
Category
Article
ISSN
1465-7392

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## Abstract p27^Kip1R^ is an isoform of p27^Kip1^, having a distinct C‐terminus. The sequences of p27^Kip1R^ required for nuclear localization and growth inhibition were determined in HeLa cells using a green fluorescence protein (GFP) as a reporter molecule. Region 153–168 and residues K168 and I1

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CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in c