A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
โ Scribed by Wang, Gan; James, Clint A.; Meanwell, Nicholas A.; Hamann, Lawrence G.; Belema, Makonen
- Book ID
- 121379277
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 508 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
As part of a study on additions to strained olefins and synthesis of strained nitrogen heterocycles, we have found that addition of methoxycsrbonylnitrene to 1,2dimethylcyclobutene, 2, and l-methylcyclobutene, 2, provides a convenient synthesis of the corresponding 5-azabicyclo[2.l.O]pentanes 2a and
The synthesis of the title compound (4) is described. ## Treatment of (3S)-[(lR)-hydroxyethyl]-(4R)- [ 3-(p-nitrobenzyloxy) carbonyl-2-0x0-[ 2-I4C] -3-diazopropan-l-yl]azetidin-2-one1 with rhodium diacetate achieved ring closure forming (5R,6S)-pnitrobenzyl-6-~(1R)-hydroxyethyl]-3,7-dioxo-[3-14C]