An Efficient Scalable Route for the Synthesis of Enantiomerically Pure tert -Butyl-(1 R ,4 S ,6 R )-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate
โ Scribed by Maton, William M.; Stazi, Federica; Manzo, Angelo Maria; Pachera, Roberta; Ribecai, Arianna; Stabile, Paolo; Perboni, Alcide; Giubellina, Nicola; Bravo, Fernando; Castoldi, Damiano; Provera, Stefano; Turco, Lucilla; Bryant, Simon; Westerduin, Pieter; Profeta, Roberto; Nalin, Arnaldo; Miserazzi, Emanuele; Spada, Simone; Mingardi, Anna; Mattioli, Mario; Andreotti, Daniele
- Book ID
- 125968596
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 579 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1083-6160
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A synthesis of cage-shaped compounds-(IS,4S,5R)-4-hydroxy-2,6diazabicyclo[3.3.0]octane and (1S,4R,5R)-4-hydroxy-2-oxa-6-azabicyclo[3.3.0]octane described. The test for enantioselective catalysis also reported.
3R)-4-Acetoxy-3-trimethylsilyl-2-azetidinone, was converted into optically pure benzyl penicillanate in seven steps (22%) using (benzyloxy)nitromethane as a reagent for ring annulation.