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A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

✍ Scribed by Keitaro Kojima; Riyako Ohhashi; Yasunori Fujita; Nanako Hamada; Yukihiro Akao; Yoshinori Nozawa; Takashi Deguchi; Masafumi Ito

Book ID: 116297037
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 835 KB
Volume: 373
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2008.06.045

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## Background: The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (cap) are still unclear. the aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2