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A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

โœ Scribed by Sheila M. Galloway; Susan K. Greenwood; Rosina B. Hill; Carole I. Bradt; Christian L. Bean


Book ID
113255984
Publisher
Elsevier Science
Year
1995
Weight
949 KB
Volume
346
Category
Article
ISSN
0165-7992

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Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O 6 position of guanine. These methyl adducts are removed from DNA by the O 6 -alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O 6 -methylguanine (O 6 meG) induces cell death in OGAT-d