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Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines

✍ Scribed by Warren E Glaab; Kenneth R Tindall; Thomas R Skopek


Book ID
114072546
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
111 KB
Volume
427
Category
Article
ISSN
0027-5107

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Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O 6 position of guanine. These methyl adducts are removed from DNA by the O 6 -alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O 6 -methylguanine (O 6 meG) induces cell death in OGAT-d