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Role of pre- and post-replicative mismatch repair in cytotoxicity of methylating antitumor agents (a review)

โœ Scribed by L. B. Gorbacheva; L. Yu. Dederer


Book ID
106491996
Publisher
Springer
Year
2009
Tongue
English
Weight
78 KB
Volume
43
Category
Article
ISSN
0091-150X

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Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O 6 position of guanine. These methyl adducts are removed from DNA by the O 6 -alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O 6 -methylguanine (O 6 meG) induces cell death in OGAT-d