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A Resin-Linker-Vector Approach to Radiopharmaceuticals Containing 18 F: Application in the Synthesis of O -(2-[ 18 F]-Fluoroethyl)- L -tyrosine

✍ Scribed by Topley, Amy C.; Isoni, Valerio; Logothetis, Thomas A.; Wynn, Duncan; Wadsworth, Harry; Gibson, Alex M. R.; Khan, Imtiaz; Wells, Neil J.; Perrio, Cécile; Brown, Richard C. D.


Book ID
118754215
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
574 KB
Volume
19
Category
Article
ISSN
0947-6539

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✍ Ganghua Tang; Xiaolan Tang; Mingfang Wang; Lei Luo; Manquan Gan; Zuhan Huang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

## Abstract A slightly modified automated commercial synthesis system for preparation of __O__‐(2‐[^18^F]fluoroethyl)‐l‐tyrosine (FET), an amino acid tracer for tumor imaging with positron emission tomography, is described. Direct nucleophilic fluorination of [^18^F]fluoride with 1,2‐di(4‐methylphe