Automated commercial synthesis system for preparation of O-(2-[18F]fluoroethyl)-L-tyrosine by direct nucleophilic displacement on a resin column

✍ Scribed by Ganghua Tang; Xiaolan Tang; Mingfang Wang; Lei Luo; Manquan Gan; Zuhan Huang

• Book ID: 102373229
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: French
• Weight: 93 KB
• Volume: 46
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.706

✦ Synopsis

Abstract

A slightly modified automated commercial synthesis system for preparation of O‐(2‐[^18^F]fluoroethyl)‐l‐tyrosine (FET), an amino acid tracer for tumor imaging with positron emission tomography, is described. Direct nucleophilic fluorination of [^18^F]fluoride with 1,2‐di(4‐methylphenylsulfonyloxy)ethane on a quaternary 4‐(4‐methylpiperidinyl)‐pyridinium functionalized polystyrene anion exchange resin gave 1‐[^18^F]‐2‐(4‐methylphenylsulfonyloxy)ethane, then [^18^F]fluoroalkylation of l‐tyrosine yielded FET. The overall radiochemical yield with no decay correction was about 8–10%, the whole synthesis time was about 52 min, and the radiochemical purity was above 95%. Copyright © 2003 John Wiley & Sons, Ltd.