𝔖 Bobbio Scriptorium
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A regulatory mutant of the trimethylamine N-oxide reductase of Escherichia coli K12

✍ Scribed by Marie-Claire Pascal; Michèle Lepelletier; Gérard Giordano; Marc Chippaux

Book ID
109316912
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
248 KB
Volume
78
Category
Article
ISSN
0378-1097

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Regulatory mutants of dihydrofolate redu
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Trimethoprim inhibits dihydrofolate reductase. Mutations conferring trimethorpim-resistance on E coli K12 result in either an altered reductase with decreased affinity for the drug, or in 2-30 fold higher levels of the enzyme. Studies of the latter class of mutants indicate that dihydrofolate reduct

Altered dihydrofolate reductase in fol r
Altered dihydrofolate reductase in fol regulatory mutants of Escherichia coli K12
✍ Sheldon, Robert 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 414 KB

Three spontaneous fol regulatory mutants contain dihydrofolate reductase molecules which differ in physical properties from enzymes of their parent strains. The enzymes were purified over 100-fold by affinity chromatography and were shown to differ in vitro in thermolability and in affinity for trim