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A re-examination of the synthesis and some properties of the in vitro metabolite, N-hydroxyphenmetrazine

✍ Scribed by R. T. Coutts; R. Dawe; A. H. Beckett

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
444 KB
Volume
2
Category
Article
ISSN
1076-5174

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✦ Synopsis

The reported synthesis of N-hydroxyphenmetrazine from phenmetrazine by the action of m-chloroperbenzoic acid could not be repeated. When the synthetic procedure was modified N-hydroxyphenmetrazine was obtained in low yield. The product had different properties from those claimed previously, but was identical to metabolically produced N-hydroxyphenmetrazine. It was characterized by means of thin-layer chromatography. combined gas chromatography and mass spectrometry, preparation of a t-butyldimethylsilyl derivative and oxidation to a mixture of nitrones. Mass spectrometry was also used to characterize these derivatives.

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