Tamoxifen metabolism in rat liver micros
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Russell M. Jones; Zhi-Xin Yuan; Chang Kee Lim
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Article
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1999
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John Wiley and Sons
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English
⚖ 127 KB
👁 1 views
Tamoxifen has been shown to be a potent liver carcinogen in rats, and generates covalent DNA adducts. Online high performance liquid chromatography/electrospray ionisation mass spectrometry (HPLC/ESI-MS) has been used to further study the metabolites of tamoxifen formed by rat liver microsomes in th