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A rationale to target the SWI/SNF complex for cancer therapy

✍ Scribed by Hohmann, Anja F.; Vakoc, Christopher R.

Book ID: 124125402
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 448 KB
Volume: 30
Category: Article
ISSN: 0168-9525
DOI: 10.1016/j.tig.2014.05.001

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## Abstract The acute myeloid leukemia 1 (AML1, RUNX1) transcription factor is a key regulator of hematopoietic differentiation that forms multi‐protein complexes with co‐regulatory proteins. These complexes are assembled at target gene promoters in nuclear microenvironments to mediate phenotypic g