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A rational design of synthetic peptide vaccine with a built-in adjuvant

โœ Scribed by DEFOORT, JEAN-PHILIPPE ;NARDELLI, BERNARDETTA ;HUANG, WOLIN ;TAM, JAMES P.


Book ID
115099313
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
664 KB
Volume
40
Category
Article
ISSN
0367-8377

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Synthetic lipopeptides are showing promise as vaccine candidates, but until now it has been very difficult to prepare them in homogeneous form. We describe the synthesis and characterization of a new water-soluble, four-branched template with a built-in lipophilic adjuvant (Pam3Cys). Through the use