A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reaction 5-substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological
β¦ LIBER β¦
A rapid and efficient route to 4- and 5-amino-3-oxocyclopentene derivatives
β Scribed by D'Ascoli, Raniero; D'Auria, Maurizio; De Mico, Antonella; Piancatelli, Giovanni; Scettri, Arrigo
- Book ID
- 126022504
- Publisher
- American Chemical Society
- Year
- 1980
- Tongue
- English
- Weight
- 391 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-3263
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Isothiazoles. Part 9. An Efficient Synthetic Route to 5-Substituted-3-amino-4-arylisothiazole 1,1-Dioxides and Their 4,5-Dihydro Derivatives. -The thiazole dioxide (I) does not react with alcohols, while the derivative (VIII) does not undergo addition with aliphatic and aromatic amines but with the