A Raney nickel — sodium hypophosphite combination system for reductive desulfurization without racemization of optically active secondary alcohol

✍ Scribed by Manabu Node; Kiyoharu Nishide; Yukihiro Shigeta; Kenichi Obata; Hiroaki Shiraki; Hideaki Kunishige

• Book ID: 104208025
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 703 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)00804-1

✦ Synopsis

Sulfides and sulfoxides bearing an optically active secondary alcohol wece desul~ with a Rmey nickel (W-2)-sodium hypophosphite combination system to give optically active alcohols in high yields without racemization. However, the combination system was not effective with sulfides whioh comprise m alkylthio group and the corresponding sulfoxides. This system exhibited the reductive desulfurlzation of benzylthio or phenylthio ether in the presence of a benzyl ether.