A randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4
✍ Scribed by Vince, Bradley; Hill, John M.; Lawitz, Eric J.; O’Riordan, William; Webster, Lynn R.; Gruener, Daniel M.; Mofsen, Ricky S.; Murillo, Abel; Donovan, Eileen; Chen, Jie; McCarville, Joseph F.; Sullivan-Bólyai, John Z.; Mayers, Douglas; Zhou, Xiao-Jian
- Book ID
- 122225654
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 857 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0168-8278
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Abbreviations: AE, adverse event; AUC, area under the plasma concentration time curve; AUC (TAU) , AUC over 12-hour dosing interval for 30 mg twice daily; C min , minimum observed plasma concentration; C max , maximum observed plasma concentration; C trough , trough concentrations; CLT/F, apparent t
Previous studies from Japan have described an association between a conserved sequence within the hepatitis C virus (HCV) genome and resistance to interferon (IFN) therapy for patients infected with HCV genotype 1b [