A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C
β Scribed by Eric J. Lawitz; Daniel Gruener; John M. Hill; Thomas Marbury; Lisa Moorehead; Anita Mathias; Guofeng Cheng; John O. Link; Kelly A. Wong; Hongmei Mo; John G. McHutchison; Diana M. Brainard
- Book ID
- 116652701
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 830 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0168-8278
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Abbreviations: AE, adverse event; AUC, area under the plasma concentration time curve; AUC (TAU) , AUC over 12-hour dosing interval for 30 mg twice daily; C min , minimum observed plasma concentration; C max , maximum observed plasma concentration; C trough , trough concentrations; CLT/F, apparent t
This study tested the hypothesis that high-dose peginterferon alfa-2a (PEG-IFNalpha-2a) for the first 12 weeks would increase early and sustained virological response (SVR) rates in patients with chronic hepatitis C genotype 1. Eight hundred ninety-six patients were randomized 1:1 to 360 microg (n =