A striking association has been demonstrated recently between mutations in amino acid residues 2209-2248 of the nonstructural protein 5a (NS5a) region of hepatitis C virus (HCV) and sustained responses to interferon in Japanese patients infected with genotype 1b. Therefore, analysis of this sequence
Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
✍ Scribed by Hofgärtner, Wolfgang T.; Polyak, Stephen J.; Sullivan, Daniel G.; Carithers, Robert L.; Gretch, David R.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 310 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Previous studies from Japan have described an association between a conserved sequence within the hepatitis C virus (HCV) genome and resistance to interferon (IFN) therapy for patients infected with HCV genotype 1b [
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A region associated with sensitivity to interferon (IFN) has been identified previously in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. A study was undertaken to determine whether the presence of mutations in the NS5A 2209-2248 sequence could serve as a predictor of re
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