Calcineurin inhibitors (CNIs) contribute to renal dysfunction following liver transplantation. This prospective, randomized, multicenter, 6-month study (with an additional 6 months of follow-up) evaluated whether everolimus with CNI reduction or discontinuation would improve renal function in mainte
A Randomized, Controlled Study to Assess the Conversion From Calcineurin-Inhibitors to Everolimus After Liver Transplantation—PROTECT
✍ Scribed by L. Fischer; J. Klempnauer; S. Beckebaum; H. J. Metselaar; P. Neuhaus; P. Schemmer; U. Settmacher; N. Heyne; P-A. Clavien; F. Muehlbacher; I. Morard; H. Wolters; W. Vogel; T. Becker; M. Sterneck; F. Lehner; C. Klein; G. Kazemier; A. Pascher; J. Schmidt; F. Rauchfuss; A. Schnitzbauer; S. Nadalin; M. Hack; S. Ladenburger; H. J. Schlitt
- Book ID
- 114806429
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 900 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1600-6135
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Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro
Renal impairment is common in patients after liver transplantation and is attributable in large part to the use of calcineurin inhibitor (CNI)-based immunosuppression. We sought to determine whether conversion to sirolimus-based immunosuppression was associated with improved renal function. In a sin