Binding of D- and L-captopril inhibitors
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Jens Antony; Nohad Gresh; Lars Olsen; Lars Hemmingsen; Christopher J. Schofield;
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Article
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2002
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John Wiley and Sons
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English
⚖ 222 KB
The bacterial Zn2+ metallo-beta-lactamase from B. fragilis is a zinc-enzyme with two potential metal ion binding sites. It cleaves the lactam ring of antibiotics, thus contributing to the acquired resistance of bacteria against antibiotics. The present study bears on the binuclear form of the enzyme