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Intermediate in β-Lactam Hydrolysis Catalyzed by a Dinuclear Zinc(II) Complex: Relevance to the Mechanism of Metallo-β-lactamase

✍ Scribed by Kaminskaia, Natalia V.; Spingler, Bernhard; Lippard, Stephen J.


Book ID
127169431
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
126 KB
Volume
123
Category
Article
ISSN
0002-7863

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## Abstract A series of highly preorganized pyrazolate‐based dinuclear zinc complexes has been studied as functional synthetic analogues of metallo‐β‐lactamases, a class of bacterial enzymes that cause serious clinical problems because of their degradation of common β‐lactam antibiotics. We have in