✦ LIBER ✦

Hydrolysis of β-Lactam Antibiotics Catalyzed by Dinuclear Zinc(II) Complexes: Functional Mimics of Metallo-β-lactamases

✍ Scribed by Kaminskaia, Natalia V.; Spingler, Bernhard; Lippard, Stephen J.

Book ID: 121240957
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 381 KB
Volume: 122
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja993704l

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Intermediate in β-Lactam Hydrolysis Cata

Intermediate in β-Lactam Hydrolysis Catalyzed by a Dinuclear Zinc(II) Complex: Relevance to the Mechanism of Metallo-β-lactamase

✍ Kaminskaia, Natalia V.; Spingler, Bernhard; Lippard, Stephen J. 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 126 KB

Biomimetic Hydrolysis of Penicillin G Ca

Biomimetic Hydrolysis of Penicillin G Catalyzed by Dinuclear Zinc(II) Complexes: Structure–Activity Correlations in β-Lactamase Model Systems

✍ Bernhard Bauer-Siebenlist; Sebastian Dechert; Franc Meyer 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 258 KB

## Abstract A series of highly preorganized pyrazolate‐based dinuclear zinc complexes has been studied as functional synthetic analogues of metallo‐β‐lactamases, a class of bacterial enzymes that cause serious clinical problems because of their degradation of common β‐lactam antibiotics. We have in