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A quantum mechanics/molecular mechanics study of the acylation reaction of TEM1 β-lactamase and penicillanate

✍ Scribed by Pitarch, Jesús; Pascual-Ahuir, Juan-Luis; Silla, Estanislao; Tuñón, Iñaki

Book ID
120248047
Publisher
Royal Society of Chemistry
Year
2000
Tongue
English
Weight
207 KB
Volume
4
Category
Article
ISSN
1472-779X

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The bacterial Zn2+ metallo-beta-lactamase from B. fragilis is a zinc-enzyme with two potential metal ion binding sites. It cleaves the lactam ring of antibiotics, thus contributing to the acquired resistance of bacteria against antibiotics. The present study bears on the binuclear form of the enzyme