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A prototype solid phase synthesis of pteridines and related heterocyclic compounds

✍ Scribed by Gibson, Colin L.; La Rosa, Salvatore; Suckling, Colin J.

Book ID
120268841
Publisher
Royal Society of Chemistry
Year
2003
Tongue
English
Weight
227 KB
Volume
1
Category
Article
ISSN
1477-0520

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πŸ“œ SIMILAR VOLUMES

A traceless solid-phase synthesis of pte
A traceless solid-phase synthesis of pteridines
✍ Colin L. Gibson; Salvatore La Rosa; Colin J. Suckling πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 109 KB

The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

Solid phase synthesis of heterocyclic co
Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas
✍ Adel Nefzi; John M. Ostresh; Jean-Philippe Meyer; Richard A. Houghten πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 207 KB

The solid phase synthesis of cyclic ureas and thioureas is described. The reduction of acylated dipeptides followed by treatment with carbonyldiimidazole or thiocarbonyldiimidazole affords the corresponding cyclic urea or thiourea in good yield and high purity. This is an example of a broader approa