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Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas

✍ Scribed by Adel Nefzi; John M. Ostresh; Jean-Philippe Meyer; Richard A. Houghten

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
207 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid phase synthesis of cyclic ureas and thioureas is described. The reduction of acylated dipeptides followed by treatment with carbonyldiimidazole or thiocarbonyldiimidazole affords the corresponding cyclic urea or thiourea in good yield and high purity. This is an example of a broader approach to the solid phase synthesis of individual heterecyclic compounds and combinatorial libraries using peptides as starting materials.

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