Esterification of Fmoc {fluo~e~-9-y~methyloxy~~bonyl) amino acid ot amino acid derivative to 4-~~ox~benzy~~cohol resin was achieved in generally good yield using a new esterScation reagent, CIP [2-~hloro~~,3-dim~th~~~m~~zo~~dini~m hexafluoro-phosphate1 or BOI [2-(benzotriazol-l-y!) oxy-1,3-dimethyli
A protocol for racemization-free loading of Fmoc-amino acids to Wang resin
β Scribed by Krishnarao Sandhya; Bhagavathula Ravindranath
- Book ID
- 108284868
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 88 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
An efficient, general, and racemization free method of covalently attaching No-F'KKXZ protected amino acids to solid supports for peptide synthesis is described. The process involves the preparation of 2,4-dichlorophenyl-Na-Fmoc-aminoaql-4-oxyn~sthylphenoxy acetates which can be used to directly and
A chromatographic assay has been developed to quantitate racemization occurring during attachment of protected amino acids to peptide synthesis resins. Acidolytic cleavage of deprotected amino acids from supports and subsequent derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey