A Precipitating Antibody to Insulin
โ Scribed by JONES, VALERIE E.; CUNLIFFE, A. C.
- Book ID
- 109617942
- Publisher
- Nature Publishing Group
- Year
- 1961
- Tongue
- English
- Weight
- 322 KB
- Volume
- 192
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/192136a0
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๐ SIMILAR VOLUMES
We immunized mice with insulin and found that those strains that develop insulin antibodies subsequently produce insulin-like activity in amount equivalent to 300-400 ng insulin per ml serum. The activity was due exclusively to IgG2 antibodies. Bioactivity could be blocked efficiently by insulin an
In the presence of anti-insulin antibody, 2-to 3-fold enhancement of 1251-insulin binding to liver membranes was observed when binding was estimated by the radioactivity of 125I-insulin bound to the membrane pellets. However, after 125I-insulin was covalently cross-linked to liver membranes using di