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A Practical Synthesis of Novel Rho-Kinase Inhibitor, (S)-4-Fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline

✍ Scribed by Shibuya, Kimiyuki; Gomi, Noriaki; Ohgiya, Tadaaki; Katsuyama, Jyunji; Masumoto, Masayuki; Sakai, Hitoshi

Book ID
118275832
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
793 KB
Volume
83
Category
Article
ISSN
0385-5414

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📜 SIMILAR VOLUMES

ChemInform Abstract: A Practical Synthes
ChemInform Abstract: A Practical Synthesis of Novel Rho-Kinase Inhibitor, (S)-4-Fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline.
✍ Noriaki Gomi; Tadaaki Ohgiya; Kimiyuki Shibuya; Jyunji Katsuyama; Masayuki Masum 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 42 KB 👁 1 views

## Abstract The synthesis of the novel inhibitor (VII) is achieved in multi‐kilogram scale overcoming two major issues: the need of developing a regioselective chlorosulfonylation reaction at C‐5 of fluoroisoquinoline and the stereochemical purity in the asymmetric construction of the methyldiazepa

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Single-crystal X-ray study T = 298 K Mean '(C±C) = 0.003 A Ê R factor = 0.058 wR factor = 0.088 Data-to-parameter ratio = 11.9 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.