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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

✍ Scribed by Yasuharu Sasaki; Masaaki Suzuki; Hiroyoshi Hidaka

Book ID: 114129276
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 191 KB
Volume: 93
Category: Article
ISSN: 0163-7258
DOI: 10.1016/s0163-7258(02)00191-2

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## Abstract The synthesis of the novel inhibitor (VII) is achieved in multi‐kilogram scale overcoming two major issues: the need of developing a regioselective chlorosulfonylation reaction at C‐5 of fluoroisoquinoline and the stereochemical purity in the asymmetric construction of the methyldiazepa