A practical synthesis of free and protected guanidino acids from amino acids
β Scribed by Bansi Lal; A.K. Gangopadhyay
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 183 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.
Simple amino acids (1) can be converted in fair to good yield into hydrazino acids (3) of like configuration by using KOCI instead of NaOCl to promote the Shestakov rearrangement of the intermediate hydantoic acids (2). It was shown fifteen years ago by Karady et al.,' and later by Custafsson,' that
A Practical Preparation of Diisopropyl Phosphoryl Protected Amino Acids. -Slow addition of hypochlorite to an alkaline solution of an amino acid (I) and (IV) and diisopropylphosphite (I) allows the preparation of N-diisopropyl phosphoryl protected amino acids (III) and (V) without racemization. -(B
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