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A practical preparation of diisopropyl phosphoryl protected amino acids

✍ Scribed by K.M.J. Brands; K. Wiedbrauk; J.M. Williams; U.-H. Dolling; P.J. Reider

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 244 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02300-4

No coin nor oath required. For personal study only.

✦ Synopsis

N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

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